The Swans midfielder has been sidelined for five months with a knee injury but scored in an hour-long appearance for the reserves side in their match against Bristol City on Wednesday.
"He is ready to play, he is training with us every day," said Sousa.
"Like at the rest of the squad and he can be in the first 11, but we will see what happens.
"We will think what is the best strategy [for Derby] and choose the best players to start the game against them."